Common symptoms of a Zoloft overdose may include vomiting, increased heart rate, and drowsiness. Overdosing on Zoloft can lead to serious health problems -- in about 1 percent of cases, such overdoses can lead to loss of life. If you overdose on Zoloft, seek medical attention immediately. What happens ? What side effects do you experience and what treatment is required ? How many pills are needed for it to be considered an overdose I'm talking about Zoloft , Effexor, Klonopin, Seroquel and Remeron How much of my Effexor should I take. It would cause an overdose: OVERDOSE Human Experience Of 1,027 cases of overdose involving sertraline hydrochloride worldwide, alone or with other drugs, there were 72 deaths (circa 1999). If your by yourself call a friend over to stay with you for about 4-5 hours time. You have taken about 225 mg. and Zoloft overdose can be fatal. If you think that you or someone else has taken an overdose of Zoloft, get help right away. If you're feeling suicidal, call your doctor, a suicide hotline, or emergency medical services. What are the effects of taking over 100 pills of Zoloft? If you see abuse, trolling, or guideline violations, click here to message us! Resources. The SW Mod team also maintains /r/SWResources. If you need help for yourself, we've got a directory of voice and chat/text hotline services and FAQs about hotlines, plus selected online resources. What happens when you combine antidepressants and marijuana? Mixing Zoloft and weed can result in a higher amount of Zoloft in your blood (so can mixing Zoloft and grapefruit juice). This is essentially equivalent to taking a higher dose of medication.